کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907220 1046340 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A model on the influence of age on immunity to infection with Mycobacterium tuberculosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
A model on the influence of age on immunity to infection with Mycobacterium tuberculosis
چکیده انگلیسی

Increasing susceptibility of the elderly to many infectious diseases is highly associated with the loss or delay in the generation of antigen-specific CD4+ T cells. For Mycobacterium tuberculosis infection, where antigen-specific CD4+ T cell derived IFN-γ is essential, such a loss can lead to a significant failure to control infection. The present paper develops a mathematical model of infection with M. tuberculosis in old mice. The model includes an early resistance to infection which is mediated by CD8+ T cells. A subsequent reversal of this phenotype results from the slow generation of CD4+ T cell mediated immunity in old age. The model simulations corroborate experimental data and hence, the model was used to test whether immunity to infection could be improved in old mice, if CD4+ T cell responses were enhanced. Our simulations indicate that boosting antigen presentation and T cell proliferation can decrease the M. tuberculosis burden in the lung.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 43, Issue 4, April 2008, Pages 275–285
نویسندگان
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