Aging and CD8+ T cell immunity to respiratory virus infections

The capacity of the immune system to mediate effective immune responses to pathogens declines with age. In the case of immune responses to newly encountered antigens, several studies have demonstrated that this decline reflects both a loss of naïve T cells and changes in the repertoire and function of these cells over time. However, comparatively little is known about the impact of age on established memory T cells pools. Here we discuss age-related changes in memory CD8+ T cell pools elicited by influenza and parainfluenza viruses and the impact of these changes on immunity in general.