کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907403 1046353 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease
چکیده انگلیسی

A large number of studies deals with the association of cholesterol and Aβ levels, however, the results are so far controversial. Whereas some studies report on increased cholesterol levels, other authors refer to an association of decreased peripheral cholesterol and the incidence of Alzheimer's disease. It is also questionable whether plasma cholesterol levels could be used as a predictive biomarker for the incidence of Alzheimer's disease. In the present report, we studied the relationship between these two parameters during aging in different transgenic mouse models of Alzheimer's disease, expressing both mutant human amyloid precursor protein and mutant human presenilin-1. Measurements of plasma cholesterol levels revealed a significant reduction in aged APP/PS1 and APP/PS1ki mice, whereas plasma levels in young and aged control mice remained almost unchanged. Furthermore, statistical analysis revealed a significant negative correlation between plasma cholesterol and brain Aβ42 levels during aging in the mice expressing both APP and PS1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 41, Issue 2, February 2006, Pages 220–224
نویسندگان
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