کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1907620 | 1046399 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant enzymes activities and protein damage in rat brain of both sexes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The theory of free radicals and accumulation of damages suggests that the reactive species of oxygen play a key role in the context of aging. Thus, for the best understanding of the aging process, the study of antioxidant defenses has to be considered as part of gerontology. The present work evaluated the enzymatic activity of the enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), and measured the amount of oxidative damage in proteins (carbonyl groups) in brains of rats of both sexes in the ages of 3-, 6-, 12- and 20-months. The results suggest that the patterns of activity and accumulation of damages can be sex-specific and related to the cycle of reproductive life of the organism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 41, Issue 4, April 2006, Pages 368–371
Journal: Experimental Gerontology - Volume 41, Issue 4, April 2006, Pages 368–371
نویسندگان
Guilherme Ehrenbrink, Fernanda Schäfer Hakenhaar, Tiago Boeira Salomon, Antonella Pilla Petrucci, Marcia Rodrigues Sandri, Mara Silveira Benfato,