کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1909729 | 1046738 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of α-tocopherol transfer protein gene disruption on Trypanosoma congolense infection in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effect of α-tocopherol transfer protein gene disruption on Trypanosoma congolense infection in mice The effect of α-tocopherol transfer protein gene disruption on Trypanosoma congolense infection in mice](/preview/png/1909729.png)
چکیده انگلیسی
At present 15 to 20 million people are estimated to be infected with pathogenic trypanosome parasites worldwide, mainly in developing countries. There are a number of factors that affect the severity of trypanosomiasis, including the nutritional status of the host. However, the relationship between micronutrient levels and trypanosomiasis outcome has yet to be reported in detail. Here, we demonstrate that the inhibition of α-tocopherol transfer protein, a determinant of the vitamin E concentration in host circulation, confers resistance to Trypanosoma congolense infection, evidently owing to oxidative damage to parasite DNA. These results suggest that transient inhibition of α-tocopherol transfer gene activity could possibly be exploited as a strategy for both the prevention and the treatment of trypanosomiasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 47, Issue 10, 15 November 2009, Pages 1408-1413
Journal: Free Radical Biology and Medicine - Volume 47, Issue 10, 15 November 2009, Pages 1408-1413
نویسندگان
Maria Shirley Herbas, Oriel M.M. Thekisoe, Noburo Inoue, Xuenan Xuan, Hiroyuki Arai, Hiroshi Suzuki,