کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1911496 | 1046819 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress-mediated arterial dysfunction in patients with metabolic syndrome: Effect of ascorbic acid
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Arterial dysfunction is a hallmark of early atherosclerosis; however, its behavior in patients with metabolic syndrome (MS) is still unclear. We investigated the role of oxidative stress on ischemia-induced flow-mediated dilatation (FMD) in patients with MS. FMD and oxidative stress, as assessed by serum levels of 8-hydroxy-2-deoxy-2-deoxyguanosine (8-OHdG), were studied in 18 MS and 30 control subjects. Thereafter, in the 18 MS patients, FMD was assessed after iv infusion of 1 g vitamin C or placebo in a randomized, double-blind, crossover design; serial blood samples were taken in peripheral circulation before and after FMD to analyze 8-OHdG. Compared to controls, MS patients had higher 8-OHdG (p < 0.001) and lower FMD (p < 0.001); 8-OHdG and FMD were inversely correlated (R = â0.74; p < 0.01). In MS patients, placebo administration did not change FMD, whereas vitamin C significantly enhanced it (p < 0.001). After placebo, ischemia-induced FMD was associated with a significant increase in 8-OHdG (p < 0.001), an effect that was counteracted by vitamin C. Vitamin C infusion was associated with an inverse correlation between the changes in FMD and oxidative stress (R = â0.67; p < 0.01). The present study shows that arterial dilatation is impaired and that enhanced oxidative stress may play a key role in patients with MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 43, Issue 5, 1 September 2007, Pages 853-859
Journal: Free Radical Biology and Medicine - Volume 43, Issue 5, 1 September 2007, Pages 853-859
نویسندگان
Roberto Cangemi, Francesco Angelico, Lorenzo Loffredo, Maria Del Ben, Pasquale Pignatelli, Alessandra Martini, Francesco Violi,