The metabolic syndrome in a memory clinic population: Relation with clinical profile and prognosis

• We compared patients by MetS status at the first presentation at a memory clinic.
• The clinical profile did not differ according to the presence or absence of MetS.
• MetS was associated with slightly worse cognitive performance in nondemented patients.
• Mets was not associated with an increased conversion rate to dementia.
• This suggests a role for MetS early in the disease process of cognitive impairment.

BackgroundThe metabolic syndrome (MetS) refers to a cluster of cardiovascular risk factors that is associated with an increased risk of cognitive impairment and dementia. It is unclear however, if the presence of the MetS is associated with a particular clinical profile or a different prognosis in patients with cognitive complaints or early dementia.ObjectivesTo compare 1) the clinical profile and 2) the prognosis of patients attending a memory clinic according to the presence or absence of MetS.DesignLongitudinal cohort.SettingMemory clinic.ParticipantsWe included and followed 86 consecutive patients (average age of 66.7 (SD 9.7)) from the Amsterdam Dementia Cohort with an MMSE > 22.MeasurementsClinical profile (neuropsychological examination, brain MRI, cerebrospinal fluid (CSF) biomarkers, clinical diagnosis) on an initial standardized diagnostic assessment was compared according to MetS status. Progression to dementia was assessed in initially nondemented patients (subjective complaints n = 40, mild cognitive impairment n = 24, follow-up available in 59).Results35 (41%) patients met the MetS criteria. Demographics were similar between patients with or without the MetS. At baseline, diagnosis, cognitive performance, severity of degenerative or vascular abnormalities on MRI, and CSF amyloid and tau levels did not differ between the groups (all p > 0.05). Among nondemented patients, however, MetS was associated with worse performance on executive function, attention & speed and visuoconstructive ability (z-scores, p < 0.05). During a mean follow-up of 3.4 years a similar proportion of patients with (4; 17%) and without (6; 17%) the MetS progressed to dementia (p = 0.45).ConclusionAmong nondemented patients presenting at a memory clinic MetS was associated with slightly worse cognitive performance (worse on tasks assessing executive functions, visuo-constructive ability, attention & speed), but conversion rate to dementia was not increased.