Genetic variations of MMP9 gene and intracerebral hemorrhage outcome: A cohort study in Chinese Han population

• There is no report about the effects of MMP9 genetic variations on ICH outcome.
• Larger cohort study on this topic in Chinese Han population was performed.
• Comprehensive analyses of MMP9 genetic variations on ICH outcome were done.
• Genetic variations of MMP9 were not significantly associated with ICH outcome.

ObjectiveTo investigate the association between genetic variations of matrix metalloproteinase 9 (MMP9) gene and intracerebral hemorrhage (ICH) outcome in Chinese Han population.MethodsThe clinical data and peripheral blood samples from the patients with ICH were collected. The patients were followed up for 3 months, and poor outcome was defined as death or dependency (modified Rankin scale score of 3–6). MassARRAY Analyser was used to genotype the tagger single nucleotide polymorphisms (SNPs) of MMP9 gene. Construction of haplotypes and genetic comparisons were performed by employing PLINK 1.0.7 software.Results181 patients with ICH were recruited between September 2009 and October 2010. Information on genetic variations and follow-up assessments were available for 169 (93.4%) patients. Independent patients at 90 days were younger than those who died or dependent (57.82 ± 13.47 vs. 66.99 ± 11.49 years, p < 0.01). In addition, independent patients had lower National Institutes of Health Stroke Scale (NIHSS) score (4[1–6] vs. 13[9–19], p < 0.01). There were no significant associations (all p > 0.05) between MMP9 genetic variations (alleles, genotypes and haplotypes) and ICH outcome after adjustment for conventional risk factors.ConclusionsThe genetic variations of MMP9 gene were not significantly associated with ICH outcome at 90 days in Chinese Han population.