کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1915300 | 1535181 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease](/preview/png/1915300.png)
چکیده انگلیسی
The expression of hippocalcin, a calcium-sensor protein of the recoverin family, and mixed lineage kinase 2 (MLK2) in Lewy bodies (LBs) was immunohistochemically examined in patients with Parkinson's disease (PD). Hippocalcin and MLK2 were colocalized in the halo of LBs, and neither protein was detected in normal pigmented neurons. Since hippocalcin binds to the C-terminal region of MLK2 [Nagata K., Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T et al., The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J 1998;17:149–1588.], it may constitutively activate MLK2. Both hippocalcin and MLK2 may be associated with the pathogenesis of PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 281, Issues 1–2, 15 June 2009, Pages 51–54
Journal: Journal of the Neurological Sciences - Volume 281, Issues 1–2, 15 June 2009, Pages 51–54
نویسندگان
Masahiro Nagao, Hideaki Hayashi,