کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1920789 1048743 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebellar Purkinje cell loss is not pathognomonic of essential tremor
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Cerebellar Purkinje cell loss is not pathognomonic of essential tremor
چکیده انگلیسی

BackgroundMost of the literature on pathology of essential tremor (ET) has reported no consistent abnormalities. Some recent studies however indicate that cerebellar Purkinje cell (PC) loss is the pathological basis of ET in most patients.ObjectiveTo compare cerebellar PC loss in ET, with normal and tremor dominant Parkinson’s disease [PD] control brains.MethodsCerebellar PC counts were performed in seven ET, six PD and two normal control brains. Three different counting methods – sectioned through nucleolus, through nucleus and through any part of PC body, were used to count the PC.ResultsThere were individual differences in the PC counts both in the ET and the PD cases. In all three subgroups, there was a reduction in the number of PC with advancing age. When the individuals of comparable age in the three subgroups were considered, there was no clear distinction between ET, PD and normal control subjects. There was no association between the degree of PC loss and the severity or the duration of ET.ConclusionOur study militates against the hypothesis that PC loss is pathognomonic of ET.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 17, Issue 1, January 2011, Pages 16–21
نویسندگان
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