کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1921305 1048765 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dopamine receptors and l-dopa-induced dyskinesia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Dopamine receptors and l-dopa-induced dyskinesia
چکیده انگلیسی

In the majority of Parkinson's disease patients, chronic dopamine replacement therapy leads to involuntary aimless movements known as l-dopa-induced dyskinesia. While mechanisms involved in dyskinesia occurrence are still unclear, dopamine receptors undoubtedly have a central role in their pathophysiology. Here we review current knowledge and evidence for their involvement in dyskinesia genesis and manifestation. We propose that an anti-dyskinetic strategy should target the D1/D3 signalling cascade, as targeting D2 receptor signalling seems to inherently convey anti-therapeutic effects deleterious to patients. As more molecular tools are made available, we will better understand the role of each receptor and its associated signalling cascade in Parkinson's disease and l-dopa-induced dyskinesia, hopefully in a way amenable to patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 15, Supplement 4, December 2009, Pages S8–S12
نویسندگان
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