کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1922552 1048813 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
چکیده انگلیسی

The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recent studies performed in PD experimental models suggest that cdk5/p25 plays a predominant role. In the present study, we examined the gyrus cinguli of cases with PD and compared them with age-matched controls, and we demonstrated an activation of the calpain/cdk5 pathway. We found an increase in the p25/p35 immunoreactivity ratio and in the expression of transcription factor E2F-1. Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 14, Issue 4, May 2008, Pages 309–313
نویسندگان
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