کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1922552 | 1048813 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease](/preview/png/1922552.png)
چکیده انگلیسی
The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recent studies performed in PD experimental models suggest that cdk5/p25 plays a predominant role. In the present study, we examined the gyrus cinguli of cases with PD and compared them with age-matched controls, and we demonstrated an activation of the calpain/cdk5 pathway. We found an increase in the p25/p35 immunoreactivity ratio and in the expression of transcription factor E2F-1. Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 14, Issue 4, May 2008, Pages 309–313
Journal: Parkinsonism & Related Disorders - Volume 14, Issue 4, May 2008, Pages 309–313
نویسندگان
Daniel Alvira, Isidre Ferrer, Javier Gutierrez-Cuesta, Beatriz Garcia-Castro, Merce Pallàs, Antoni Camins,