دانلود مقالات ISI درباره MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine + ترجمه فارسی

استرس اکسیداتیو، اختلال در عملکرد میتوکندری و بیماری های نوروژنیک؛ بینش مکانیکی

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; LRRK2, leucine-rich repeat kinase 2; HTRA2, high temperature requirement protein A2; PD, Parkinson disease; PINK1, PTEN-induced putative kinase 1; IMS, intermembrane space; OMM, outer mitochondrial membr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

محدودیت غذایی در بیو نور انرژی مغزی و حالت ردوکس

Dietary restriction in cerebral bioenergetics and redox state

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AD, Alzheimer′s disease; CR, caloric restriction; FR, food restriction; IF, intermittent fasting; KA, kainic acid; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NOS, nitric oxide synthase; PD, Parkinson′s disease; PTZ, pentylenetetrazole; ROS, react

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

موضع گیری ایمونوهیستوشیمیایی پروتئین های مربوط به آپوپتوزوم در بدن لوی در بیماری پارکینسون و دمانس با بدنهای لوی

Immunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson׳s disease and dementia with Lewy bodies

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson׳s disease; CARD, caspase recruitment domain; TUNEL, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling; DLB, dementia with Lewy bodies; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP±,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

اختلالات جنسی در بیماری پارکینسون و سایر اختلالات حرکتی

Sex differences in Parkinson's disease and other movement disorders

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson's disease; HD, Huntington's disease; TS, Tourette's syndrome; SNpc and SNpr, substantia nigra pars compacta and pars reticulata; DA, dopamine; HRT, hormone replacement therapy; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MA, methamph

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Medicinal plant Combretum leprosum mart ameliorates motor, biochemical and molecular alterations in a Parkinson's disease model induced by MPTP

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; DA, Dopamine; DAT, Dopamine Transporter; DOPAC, 3,4-Dihydroxyphenylacetic Acid; PD, Parkinson's Disease; C.l.EE, Combretum Leprosum Ethanolic Extract; HVA, Homovanillic Acid; MPTP, 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine; TH, Tyrosine HydroxilaseComb

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson's disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; ChAT, choline acetyl transferase; DA, dopaminergic; Dtx-UII, diphtheria toxin coupled to urotensin II; Iba-1, ionized calcium-binding adaptor molecule 1; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NADPH, nicotinamide adenine dinucleotide phosphat

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Silibinin suppresses astroglial activation in a mouse model of acute Parkinson׳s disease by modulating the ERK and JNK signaling pathways

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson׳s disease; MPP+, 1-methyl-4-phenylpyridine; TH, Tyrosine hydroxylase; GFAP, Glial fibrillary acidic protein; Iba-1, Ionized calcium binding adapter molecule-1MPTP; Astrocyte; Parkinson׳s di

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

A quantitative LC–MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; %CV, percent coefficient of variation; IS, internal standard; LLOQ, lower limit of quantification; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MRM, multiple reaction monitoring; NL-1, 5-[3,5-di-tert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidine-2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism – An abscopal neuroprotective effect

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; GFAP, glial fibrillary acidic protein; IBA1, ionized calcium-binding adapter molecule 1; LED, light-emitting device; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NIr, near infrared light; PBM, photobiomodulation; SNc, substantia nigra pars compacta

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Reverse microdialysis of a 5-HT2A receptor antagonist alters extracellular glutamate levels in the striatum of the MPTP mouse model of Parkinson’s disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; L-DOPA, L-3,4-dihydroxyphenylalanine; 5-HT, serotoninGlutamate; M100907; Microdialysis; Parkinsonism; MPTP; Serotonin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; cdk5, cyclin-dependent kinase 5; DAT, dopamine transporter; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; H2O2, hydrogen peroxide; miRNA, microRNA; MPP, methyl phenyl pyridinium; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PBS

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Anti-dyskinetic effect of anpirtoline in animal models of L-DOPA-induced dyskinesia

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; 6-OHDA, 6-hydroxy-dopamine; AIMs, abnormal involuntary movements; DA, dopamine; LID, L-DOPA-induced dyskinesia; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; TH, tyrosine hydroxylaseDyskinesia; L-DOPA; Parkinson's disease; 6

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

5-HT1 receptor agonists for the treatment of L-DOPA-induced dyskinesia: From animal models to clinical investigation

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; 6-OHDA, 6-hydroxydopamine; AIMs, Abnormal involuntary movements; DA, Dopamine; L-DOPA, L-3,4-dihydroxyphenylalanine; LID, L-DOPA-induced dyskinesia; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Partkinson's disease6-OHDA; Dopamine; Serotonin; L

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Antiparkinsonian activity of some 9-N-, O-, S- and C-derivatives of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; CC, column chromatography; DMF, dimethylformamide; DMSO, dimethylsulfoxide; l-DOPA, l-3,4-dihydrophenylalanine; MAO, monoamine oxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NBS, N-bromosuccinimide; PD, Parkinson’s disease; r.t., room temper

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+, 1-methyl-4-phenylpyridinium; 3-MT, 3-methoxytyramine; MHPG, 3-methoxy-4-hydroxyphenylglycol; DOPAC, 3,4-dihydroxymethylphenylacetic acid; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytryptami

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: Insights from a transgenic mouse model

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; aSyn, α-synuclein; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; DD, dark–dark; DA, dopamine; FDR, fast delayed rectifier; GABA, gamma-aminobutyric acid; BK, large‐conductance Ca2 + activated K+ channels; LD, light–dark; MAO, Monoamine oxidase; PVN,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Increased vulnerability of parkin knock down PC12 cells to hydrogen peroxide toxicity: The role of salsolinol and NM-salsolinol

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AR-JP, autosomal recessive juvenile Parkinson’s disease; COMT, catechol-O-methyltransferase; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; MAO, monoamine oxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MTT, methylthiazol tetr

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Number of CAG repeats in POLG1 and its association with Parkinson disease in the Norwegian population

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson disease; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; POLG, polymerase gamma; UPDRS, unified Parkinson disease rating scale; HY, Hoehn and Yahr scale; PIGD, postural instability and gait difficulty; TD, tremor dominantParkinsonism; Po

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Amelioration of rotenone-induced dopaminergic cell death in the striatum by oxytocin treatment

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; OT, oxytocin; PD, Parkinson's disease; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OTR, oxytocin receptors; DMSO, dimethyl sulfoxide; SNc, substantia nigra pars compacta; VTA, ventral tegmental area; TH, tyrosine hydroxylase; Bcl-2, B-cell lymphom

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Partial dopamine depletion in MPTP-treated mice differentially altered motor skill learning and action control

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; DA, dopamine; DAT, dopamine transporter; ERK, extracellular signal-regulated kinase; i.p, intraperitoneal; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; s.c, subcutaneous; TH, tyrosine hydroxylaseAccelerating rotarod; Motor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Cellular localization of dopamine receptors in the gastric mucosa of rats

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Dopamine receptor; Gastric mucosa; Immunofluorescent; Chief cell; Parietal cellDA, dopamine; IR, immunoreactivity; GI, gastrointestinal; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; real-time RT-PCR, real-time reverse-transcription polymerase chain

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MAO-B, monoamine oxidase-B; PPAR, peroxisome proliferator-activated receptor; SNc, substantia nigra pars compacta; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 6-OHDA, 6-hydroxydopamine; VTA, ventral tegmental area; TH, tyrosine hydroxylasePPAR; Pi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP+-induced mitochondrial dysfunctions in neuronal cells

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; SDM, serum deficient media; CM, complete media; MPP+, 1-methyl-4-phenylpyridinium ion; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SN, substantia nigra; ST, striatum; DN, dopaminergic neuron; TH, tyrosine hydroxylase; CMAPS, cell-based mitochondri

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Voltage-gated calcium channels and Parkinson's disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Ca2+, calcium ion; CaV, voltage-gated calcium channel; L-DOPA, L-3,4-dihydroxyphenylalanine; 6-OHDA, 6-hydroxydopamine; mRNA, messenger RNA; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PCR, polymerase chain reaction; RT, reverse transcription; SN,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Animal models of l-DOPA–induced dyskinesia: an update on the current options

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; l-DOPA-induced dyskinesia; 6-OHDA; MPTP; animal models; abnormal involuntary movements; Parkinson's diseaseAIMs, abnormal involuntary movements; LID, l-DOPA-induced dyskinesia; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MFB, medial forebrain bund

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Targeting oxidative stress, mitochondrial dysfunction and neuroinflammatory signaling by selective cyclooxygenase (COX)-2 inhibitors mitigates MPTP-induced neurotoxicity in mice

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; ANOVA, analysis of variance; COX, cyclooxygenase; HEPES, 5-hydroxytryptamine (5-HT); i.p., intraperitoneal; iNOS, inducible nitric oxide synthase; MAO, monoamine oxidase; MDA, malondialdehyde; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MTT, 3-(4,

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Changes of gene expression profiles in the cervical spinal cord by acupuncture in an MPTP-intoxicated mouse model: Microarray analysis

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; DTT, dithiothreitol; DAT, dopamine transporter; 6-OHDA, 6-hydroxydopamine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SNpc, substantia nigra pars compac

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; DA, dopamine; DAT, dopamine transporter; TH, tyrosine hydroxylase; SN-PC, substantia nigra pars compacta; PRAC, parallel rod activity chamber; ANOVA, analysis of varianceTyrosine hydroxylase; Dopamine; D

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Six questions on the subthalamic nucleus: lessons from animal models and from stimulated patients

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; basal ganglia; OCD; perseveration; motivation; DBS; high-frequency stimulationDBS, deep brain stimulation; HFS, high-frequency stimulation; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; STN, subthalamic nucleus; 5-CSRTT, 5-c

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Gene–environment interactions: Key to unraveling the mystery of Parkinson's disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson's disease; SN, substantia nigra; LPS, lipopolysaccharide; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NOS, nitric oxide synthase; LRRK2, Leucine-rich repeat kinase 2; PINK1, PTEN-induced putative kinase 1; GWAS, genome-wide associati

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2011 سفارش ترجمه

Time course of MPTP toxicity on translational control protein expression in mice brain

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; eIF2α, eukaryotic initiation factor 2α; mTOR, mammalian target of rapamycin; PKR, double-stranded RNA-protein dependent kinase; p70S6K, ribosomal p70S6 kinase; MPP+, 1-methyl-4-phenylpyridinium ion; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD,

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Nest building performance following MPTP toxicity in mice

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; DA, dopamine; DAT, dopamine transporter; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanilic acid; l-DOPA, l-3,4-dihydroxyphenylalanine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; SEM, standard error of the mean; TH,

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: Clinical relevance

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; DA, dopamine; DOPAC, dihydroxyphenylacetic acid; GSH, glutathione; MAO-B, monoamine oxidase-B; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+, 1- methyl-4-phenylpyridinium; TH, tyrosine hydroxylaseZonisamide; Epilepsy; MPTP; MAO-B; Mice; Parkins

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP+-induced neurotoxicity on dopaminergic nerve terminals

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; BDNF, brain-derived neurotrophic factor; DCG-IV, 2S:2′R:3′R:-2-(2′3′-dicarboxycycloropropyl)glycine; MPP+, 1-methyl-4-phenylpyridinium ion; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; QA, quinolinic acidDopamine microdialysis; Quinolinic acid lesi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson's disease; SN, substantia nigra; NMDA, N-methyl-d-aspartate; IGF-1, insulin-like growth factor-1; CNS, central nervous system; MPP+, 1-methyl-4-phenylpyridiniumion; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; GSK-3beta, glycogen synt

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Genes regulated in MPTP-treated macaques and human Parkinson's disease suggest a common signature in prefrontal cortex

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; PFC, prefrontal cortex; NER, normalized expression rate; FDR, false discovery rateMicroarray; Quantitative PCR; Monkey; Human; Parkinson's disease; MPTP; Brain; Prefrontal cortex

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Akt, protein kinase B; BSA, bovine serum albumin; DA, dopamine; GSK3, glycogen synthase kinase-3; 6-OHDA, 6-hydroxydopamine; L-Dopa, Levodopa; LID, L-Dopa-induced dyskinesias; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; mTORC2, mTOR complex 2; NMD

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson's disease; MPP+, 1-methyl-4-phenyl pyridinium; PI3K, phosphatidylinositol 3-kinase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; COX, cyclooxygenase; NSAIDs, nonsteroidal antiinflammatory drugs; MEK, MAP-ERK kinase; MAP, mitogen activ

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Effects of cysteamine on MPTP-induced dopaminergic neurodegeneration in mice

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson's disease; DA, dopamine; MPP+, 1-methyl-4- phenylpyridinium ions; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; GSH, glutathione; MDA, malondialdehyde; SNpc, substantia nigra pars compact; ROS, reactive oxygen species; SOD, superoxide

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Adenosine A1 receptors contribute to mitochondria vulnerability to pro-oxidant stressors

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPP+, l-methyl-4-phenylpyridinium; RTN, rotenone; PQ, paraquat; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; A1ko, A1 knock-out; N0840, N6-cyclopentyl-9-methyladenine; CCPA, 2-chloro-N6-cyclopentyladenosine; DCFH-DA, dichlorofluorescin diacetate; C

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; DA, dopamine; DSP-4, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine; ISI, interspike interval; ISIH, interspike interval histogram; LC, locus coeruleus; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NA, noradrenalin; PBS, phosphate buffered saline; PD

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

VTA neurons show a potentially protective transcriptional response to MPTP

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; LCM, Laser capture microdissection; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SN, substantia nigra; VTA, ventral tegmental areaMicroarray; Substantia nigra; Ventral tegmental area

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AD, Alzheimer's Disease; APP, amyloid precursor protein; Aβ, amyloid β peptide; KGDHC, α-ketoglutarate dehydrogenase complex; ETC, electron transport chain; Htt, huntingtin; HD, Huntington's Disease; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3NP

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Gene expression profiling in progressively MPTP-lesioned macaques reveals molecular pathways associated with sporadic Parkinson's disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AREs, androgen receptor binding sites; β-TrCP, β-transducin repeat-containing protein; GO, Gene Ontology; REST, RE1-silencing transcription factor; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SN, substantia nigra pars compacta; STR, striatum; TCF7

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2010 سفارش ترجمه

Cytosolic labile zinc accumulation in degenerating dopaminergic neurons of mouse brain after MPTP treatment

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson's disease; DA, dopamine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SNpc, substantia nigra pars compacta; TH, tyrosine hydroxylaseParkinson's disease; Substantia nigra; Dopamine; Synaptic zinc; Apoptosis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; ASK1, apoptosis signal-regulating kinase 1; Hsp, heat shock protein; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MPP+, 1-methyl-4-pyridinium; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD, Parkinson's disease; PGC-1α, pe

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; PD, Parkinson's disease; DA, dopaminergic; SNc, substantia nigra pars compacta; NMDA, N-methyl-d-aspartate; DNQX, 6,7-dinitroquinoxaline-2,3(1H,4H)-dione; MAPK, mitogen-activated protein kinase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; JNK, c-J

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; BSA, bovine serum albumin; DAPI, 4′,6-diamidino-2-phenylindole; DMEM, Dulbecco's modified essential medium; FBS, fetal bovine serum; GFAP, glial fibrillary acidic protein; HS, horse serum; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NeuN, neuron-s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; SN, substantia nigra; PD, Parkinson's disease; MPP+, 1-methyl-4-phenylpyridinium; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; DMT1, divalent metal transporter 1; IRE, iron responsive element; TfR, transferrin receptor; UTR, untranslational region;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration

Keywords: MPTP، 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AD, Alzheimer's disease; CAD, Cath.a differentiated; C2-ceramide, N-acetyl-sphingosine; mPTP, mitochondrial permeability transition pore; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MTT, 3-(4,5-dimethyl-thiazol-2yl)-2,5-diphenyltetrazolium bromide

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه