Adenosine A1 receptors contribute to mitochondria vulnerability to pro-oxidant stressors

A1 adenosine receptors are highly expressed in the central nervous system. Mitochondrial function is a major player in adenosine receptors-mediated effects. Here, by using mice with genetic deletion of the A1 receptor, we addressed the existence of a relationship between mitochondria functions and adenosine A1 receptor. Mitochondrial functions and effects of MPP+ in primary mixed cultures are influenced by the presence of the A1 receptor, demonstrating, for the first time, the mitochondrial localization of the adenosine A1 receptor and suggesting a role for this receptor as a mitochondrial vulnerability factor.