Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage

• Beneficial, non-cytotoxic effect of cerium oxide nanoparticles on stromal cells.
• Supporting a prospective therapeutical approach of such particles.
• Protection of stromal cells against the oxidative damage.

Recently, it has been published that cerium (Ce) oxide nanoparticles (CNP; nanoceria) are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF) has already been observed. However, the effect on important parameters such as cell death, proliferation and redox state of the cells needs further clarification. Here, we present that nanoceria prevent HDF from reactive oxygen species (ROS)-induced cell death and stimulate proliferation due to the antioxidative property of these particles.

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