کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1924343 1048955 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The changed immunolocalization of START-domain-containing 6 (StarD6) during the development of testes in rat perinatal hypothyroidism
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The changed immunolocalization of START-domain-containing 6 (StarD6) during the development of testes in rat perinatal hypothyroidism
چکیده انگلیسی
Thyroid hormones have an essential role in maintaining the normal developmental structure of testes during the neonatal stage. START-domain-containing 6 (StarD6) is exclusively expressed in germ cells during spermatogenesis; however, its biological role in rat perinatal hypothyroidism is not clear. After hypothyroidism was induced by daily administration of 0.05% 6-propyl-2-thiouracil (PTU), the pattern of StarD6 immunolocalization was examined from gestation day 15 to postnatal day 49. In normal rats, the labelling of StarD6 was confined to the germ cells from the third-week postpartum. In contrast, its immunoreactivity in hypothyroidal rats was not detected until the fourth-week postpartum. The immunolocalization pattern of StarD6 differed from that of normal adult rats during the seventh-week postpartum. StarD6 was clearly detected in the Leydig cells of the perinatal hypothyroid rats from the fifth-week postpartum. Therefore, StarD6 may play a pivotal role, not only in the spermatogenesis of normal rats, but also in the steroidogenesis of Leydig cells under perinatal hypothyroidism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 109, Issue 4, 1 August 2007, Pages 315-321
نویسندگان
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