کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1969308 1059765 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of plasmatic MMP-8, MMP-9, TIMP-1 and MPO levels in obese and lean women
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Evaluation of plasmatic MMP-8, MMP-9, TIMP-1 and MPO levels in obese and lean women
چکیده انگلیسی

ObjectivesTo compare the plasma concentrations of matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-1, MMP-8, and myeloperoxidase (MPO) for obese and lean women.Design and methodsWe recruited 30 lean and 36 obese women without comorbidities. The MMP-9, TIMP-1, and MMP-8 levels were measured using enzyme-linked immunosorbent assay (ELISA). MPO activity was assessed by a colorimetric assay.ResultsObese women had higher MMP-9 levels and MMP-9:TIMP-1 ratios than lean women. Conversely, the MMP-8 levels and MMP-8:TIMP-1 ratios in the obese women were significantly lower than those in the lean women despite neutrophil activation, which was assessed by MPO activity.ConclusionWe observed that MMP-9 and MMP-8 had distinct profiles, which suggested that these 2 enzymes play different roles in obesity.


► We show increase and reduced levels of MMP-9 and MMP-8 comparing obese versus lean women.
► Neutrophil is activates in obesity.
► Suggest different biological meaning of these two enzymes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 45, Issue 6, April 2012, Pages 412–415
نویسندگان
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