کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1969380 1538891 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of the URIT-2900 Automated Hematology Analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Evaluation of the URIT-2900 Automated Hematology Analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations
چکیده انگلیسی

BackgroundThe effectiveness of the URIT-2900 Hematology Analyzer for screening of hemoglobinopathies commonly found in Southeast Asian populations was examined.MethodsAppropriate cut-off values of MCV and MCH for screening of α0 and β thalassemias were derived from the receiver operator characteristic curve conducted initially on 279 subjects with various thalassemia genotypes. Validation was performed additionally in a cohort of another unrelated 313 subjects.ResultsThe best cut off values of MCV and MCH were found to be 78 fL and 27 pg, respectively. Using these cut off values in combination with the dichlorophenolindophenol test in screening of α0 thalassemia, β thalassemia and Hb E in a cohort study revealed 100% sensitivity, 79.6% specificity, 80.0% positive predictive value and 100% negative predictive value.ConclusionThe combined blood cell counting using the URIT-2900 Automated Hematology Analyzer and dichlorophenolindophenol test is suitable for population screening of thalassemia and hemoglobinopathies in Southeast Asia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 44, Issues 10–11, July 2011, Pages 889–893
نویسندگان
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