کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1969406 | 1059769 | 2013 | 5 صفحه PDF | دانلود رایگان |
Background/aimsThe incidence of metabolic syndrome (MS) in hepatitis C patients in Taiwan is not well known. Although the ratio of CD4+/CD8+ T lymphocytes is considered to possibly affect the pathogenesis of hepatitis C, the effects of MS on CD4+/CD8+ T lymphocytes remain unknown. The aims of this study to assess (1) the incidence of MS, (2) the inflammation status and fatty changes of liver, and (3) changes in their CD4+/CD8+ T-lymphocyte ratio in patients with hepatitis C.Methods60 hepatitis C patients were classified into MS or non-MS group. The terms of anthropometric data, MS components, and T-lymphocytes were assessed.ResultsThe proportion of hepatitis C patients suffering from MS was 26.7% in this study. The CD4+/CD8+ T-lymphocyte ratios were higher in patients with MS than non-MS group. Hepatitis C patients with MS also had higher levels of ferritin than non-MS. Moreover, the level of ferritin positively correlated with the severity of fatty liver. The CD4+/CD8+ T-lymphocyte ratio is also positively correlated with ferritin level and the severity of fatty liver.ConclusionsHepatitis C patients with MS had higher ratio of CD4+/CD8+ T lymphocyte, which is associated with a high inflammatory response and a fatty change of liver.
Journal: Clinical Biochemistry - Volume 46, Issue 9, June 2013, Pages 745–749