کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1969733 1059779 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV–HBV co-infected patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV–HBV co-infected patients
چکیده انگلیسی

ObjectivesTo determine adenosine deaminase (ADA) activity as a possible diagnostic marker in HIV and HIV–HBV co-infected patients.Design and methodsBlood samples were collected from 72 healthy, 33 HIV positive and 30 HIV–HBV co-infected subjects. Blood CD4+ cell count was recorded and serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total ADA, and ADA1 and ADA2 isoenzyme activities were determined.ResultsSerum ALT, AST, total ADA and ADA2 isoenzyme activities were significantly higher in HIV positive and HIV–HBV co-infected groups compare to the control (p < 0.05), whereas serum ALP showed no differences between groups. CD4+ cell counts markedly decreased in all patients and showed a significant inverse correlation with ADA activities (R2 = 0.589, p < 0.001).ConclusionsSerum ADA was significantly increased in HIV and HIV–HBV co-infections. Therefore, because of its low cost and simplicity to perform, ADA activity might be considered as a useful diagnostic tool among the other markers in these diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 44, Issue 12, August 2011, Pages 980–983
نویسندگان
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