کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1969829 1538894 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased serum S-100B and neuron specific enolase — Potential markers of early nervous system involvement in essential hypertension
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Increased serum S-100B and neuron specific enolase — Potential markers of early nervous system involvement in essential hypertension
چکیده انگلیسی

ObjectivesTo investigate the occurrence of subclinical neurologic involvement in patients with essential hypertension employing serum biochemical markers.Design and methodsFifty patients with essential hypertension and 42 controls with no clinical evidence of neurological disease were recruited. Serum S100B protein and neuron specific enolase (NSE) were determined by employing immunoassay kits from CanAg Diagnostics AB (Sweden). Brain MRI and fundoscopic exploration were conducted.ResultsS-100B and NSE levels were significantly higher in hypertensive patients than in controls. In hypertensive patients, multivariate analysis revealed that NSE was independently associated with two variables expressing severity of hypertension: diastolic blood pressure and grade of retinopathy. Brain MRI studies demonstrated higher NSE levels in patients with more severe white matter lesions.ConclusionsRaised NSE levels are associated with a higher severity of hypertension and of white matter lesions, providing preliminary evidence that suggests the presence of silent brain damage in a subset of hypertensive patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 44, Issues 2–3, February 2011, Pages 154–159
نویسندگان
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