کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1970346 | 1059802 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Preliminary evidence of a reduced serum level of fibroblast growth factor 19 in patients with biopsy-proven nonalcoholic fatty liver disease Preliminary evidence of a reduced serum level of fibroblast growth factor 19 in patients with biopsy-proven nonalcoholic fatty liver disease](/preview/png/1970346.png)
ObjectivesWe sought to determine whether serum concentrations of fibroblast growth factor 19 (FGF19) – an ileum-derived enterokine which plays a role in the control of glucose and lipid homeostasis – are altered in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD).Design and methodsSerum levels of FGF19 were measured using enzyme-linked immunosorbent assay in 91 patients with biopsy-proven NAFLD and 74 controls.ResultsFGF19 levels were significantly lower in patients with biopsy-proven NAFLD (median: 130 pg/mL) than in controls (median: 210 pg/mL, P < 0.001). Serum FGF19 levels were significantly but modestly associated with hepatocyte ballooning scores in univariate analysis (r = − 0.25, P < 0.05) but not after adjustment for potential confounders (β = − 0.18; t = 1.78, P = 0.08).ConclusionsThis pilot study suggests that serum FGF19 levels are decreased in patients with NAFLD but are not independently associated with liver histology findings.
► Fibroblast growth factor 19 (FGF19) may play a role in human metabolic disorders.
► We found low levels of FGF19 in nonalcoholic fatty liver disease.
► Levels of FGF19 were modestly associated with hepatocyte ballooning scores.
► The association with ballooning did not persist after multivariable analysis.
Journal: Clinical Biochemistry - Volume 45, Issue 9, June 2012, Pages 655–658