Interleukin-23 serum levels in patients affected by peripheral arterial disease

ObjectivesTo clarify whether interleukin (IL)-23 is involved in peripheral arterial disease (PAD).Design and methodsWe evaluated IL-23 serum levels, in 29 patients suffering from lower extremity PAD and in 30 healthy subjects.ResultsIL-23 serum levels were higher during the three times (T0, T1 and T2) compared to the control group, although only statistically significant for T0 and T2: T0 (15.83 ± 22.08 vs. 8.08 ± 8.62 pg ml, p = 0.026), T1 (16.10 ± 23.71 vs. 8.08 ± 8.62 pg/ml, p = 0.101), T2 (15.06 ± 16.72 vs. 8.08 ± 8.62 pg/ml, p = 0.005).ConclusionFor the first time, our data gives us reason to believe there is an involvement of IL-23 in PAD.

► We evaluated IL-23 serum levels, in 29 patients suffering from lower PAD.
► IL-23 serum levels were higher compared to the control group.
► IL-23 serum levels were higher in patients undergoing LEB with autogenous vein.