کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1970829 1538889 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C
چکیده انگلیسی

ObjectivesWhether new biomarkers contribute significantly to the existing, simple noninvasive test (comprising of routine laboratory parameters such as the AST to platelet ratio index (APRI)) for predicting liver fibrosis remains unknown.MethodsWe measured 7 biomarkers in 91 patients with chronic hepatitis C (CHC): haptoglobin, apolipoprotein A1, α2-macroglobulin, hyaluronic acid, type III procollagenic peptide, matrix metalloproteinase-2, and tissue inhibitor of metalloproteinase-1.ResultsThe “multibiomarker” score (based on regression coefficients of significant biomarkers) is an independent predictive factor for significant fibrosis [APRI-adjusted odds ratio, 2.41 (95% CI, 1.28 to 4.55)]. However, the incorporation of the multibiomarker score into the APRI resulted in only a small diagnostic improvement [0.83 (95% CI, 0.74 to 0.92) vs. 0.79 (0.69 to 0.89); p = 0.19].ConclusionsFor assessing significant fibrosis in individual CHC patients, the 7 contemporary biomarkers that we studied add only modestly to the readily available, simple noninvasive index.


► We measure 7 new biomarkers for noninvasive assessment in 91 patients with chronic hepatitis C.
► Multiple biomarker score based on their regression coefficients is an independent predictive factor for significant fibrosis.
► The incorporation of the multiple biomarker score into AST to platelet ratio index results in only a small improvement of about 4%.
► New biomarkers add only modestly to the readily available, simple noninvasive index.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 44, Issues 17–18, December 2011, Pages 1396–1399
نویسندگان
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