کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971011 1538903 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered amino acid homeostasis in subjects affected by fibromyalgia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Altered amino acid homeostasis in subjects affected by fibromyalgia
چکیده انگلیسی

ObjectivesTo evaluate plasma amino acid (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters.Design and methods20 AAs were assessed in 34 FM patients and in 18 healthy volunteers by means of a modified version of the Waters picotag method.ResultsSignificant lower plasma taurine, alanine, tyrosine (Tyr), valine, methionine, phenylalanine and threonine concentrations, and the sum of essential AAs were observed in FM patients vs healthy controls (P < 0.05). Tyr CAA' ratio and the sum of AAs competing with tryptophan for brain uptake were significantly reduced in FM (P < 0.05). A significant correlation was found between FM clinical parameters and certain AAs.ConclusionsOur results suggest probable defects of gut malabsorption of certain AAs in FM patients. Moreover, given the reduced Tyr CAA' ratio in FM patients, a possible impairment of the cathecolaminergic system in the FM syndrome may be suggested.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 42, Issues 10–11, July 2009, Pages 1064–1070
نویسندگان
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