کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971028 1538903 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure
چکیده انگلیسی

Objectives(i) To characterize the polymorphism of arginase 1 (ARG1), a new candidate gene in coronary heart disease (CHD), in the Algerian population; (ii) To evaluate the effect of common ARG1 single nucleotide polymorphisms (SNPs) on blood pressure (BP) values; and (iii) To compare the data with those previously obtained in French populations.MethodsEleven ARG1 SNPs selected from databases were characterized in a representative sample of 117 Algerian and 92 French males free of CHD. Relevant SNPs for association studies with BP were selected on the basis of their allele frequencies and pairwise linkage disequilibrium.ResultsARG1 allele frequencies and haplotype distribution significantly differed between Algerian and French subjects. The rs2781667C/T polymorphism was associated with decreased systolic BP in Algerian subjects. This association contrasted with previous data we reported in the French population. The discrepancy would be explained by the difference in haplotype distribution between Algerian and French subjects.ConclusionThese data support the role of ARG1 in vascular pathophysiology, but the functional mutations remain to be identified.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 42, Issues 10–11, July 2009, Pages 1178–1182
نویسندگان
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