کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971160 1538896 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma homocysteine—a marker of vascular disease in elderly patients with mental illness
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Plasma homocysteine—a marker of vascular disease in elderly patients with mental illness
چکیده انگلیسی

BackgroundTotal plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease.MethodWe investigated the influence of cobalamin/folate status and renal function on the association between plasma tHcy levels and vascular disease.ResultsThere was a similar degree of significant difference in plasma tHcy levels between patients with and without vascular disease in all enrolled patients and in a group of patients where all those with signs of cobalamin/folate deficiency and/or impaired renal function had been excluded. Furthermore, logistic regression analysis showed that the age-adjusted plasma tHcy was the main predictor of vascular disease in both groups of patients.ConclusionThe findings suggest that the presence of vascular disease itself is associated with elevated levels of plasma tHcy. Plasma tHcy might be a marker of vascular disease in elderly patients with mental illness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 43, Issues 13–14, September 2010, Pages 1056–1059
نویسندگان
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