کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971171 1538896 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of apoptotic markers BCL-2 and bax in chronic hepatitis C virus patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Expression of apoptotic markers BCL-2 and bax in chronic hepatitis C virus patients
چکیده انگلیسی

ObjectivesHepatitis C viral infection(HCV) influence the susceptibility to apoptosis. This could lead to insufficient antiviral immune response and persistent viral infection.Design and methodsGroup 1: chronic HCV patients with liver cirrhosis and ascites. Group 2: chronic HCV patients without liver cirrhosis and group 3: healthy subjects as control group. Bcl-2 and Bax expression were evaluated by flowcytometry.ResultsHCV patients (with cirrhosis and ascites) had a statistically significantly low Bcl-2 expression, a significantly high Bax expression and a significantly decreased Bcl-2/Bax ratio compared with controls. While, the results are inverted in the other HCV group. Both groups of HCV, Bcl-2/Bax ratio showed a significant positive correlation with Bcl-2 and a significantly negative correlation with Bax.ConclusionsChronic HCV exhibit a deregulation of apoptosis with the disease progression. This provides an insight into the pathogenesis of chronic HCV infection, and may contribute to the therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 43, Issues 13–14, September 2010, Pages 1112–1117
نویسندگان
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