کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1971293 | 1538898 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy? Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?](/preview/png/1971293.png)
Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in relation to risk factors for DN in T2DM patients with (UA, n = 27) and without albuminuria (NA, n = 48) and controls (CO, n = 28). MMP-8 and -9 levels were highest in UA patients (P < 0.01). Of UA patients, 93% had at least one MMP increased, compared to 78% of NA patients and 46% of CO (P = 0.001). Age, diabetes duration, BMI, systolic blood pressure, fasting plasma glucose, HbA1c and renal function were determinants of MMP-8 and -9 (P < 0.05). In summary, MMP-8 and -9 are highest in T2DM UA patients. MMP-9, showed the strongest associations with clinical parameters related to DN.
Journal: Clinical Biochemistry - Volume 43, Issues 7–8, May 2010, Pages 635–639