کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1971609 1538910 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urinary IL-18: A marker of contrast-induced nephropathy following percutaneous coronary intervention?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Urinary IL-18: A marker of contrast-induced nephropathy following percutaneous coronary intervention?
چکیده انگلیسی

ObjectivesContrast-induced nephropathy (CIN) is a complication that is underestimated in clinical practice after cardiac catheterization. Recently, the value of interleukin (IL)-18 as a novel biomarker for the detection of acute renal failure has been highlighted. In the present study, we sought to investigate whether urine IL-18 may be an early diagnostic marker of CIN.Design and methodsWe performed a nested case-control study using a hospital based cohort of all patients (n = 157) admitted for elective PCI for stable angina to the Uludag University School of Medicine between February 2007 and June 2007. We identified 15 patients (9.5%) with CIN. Controls were matched with cases at an attempted 2.5:1 ratio by age and gender. Urinary IL-18 values were measured before as well as 24 and 72 h after the PCI.ResultsNo statistically significant differences in urine IL-18 were detected between cases (n = 15) and controls (n = 36) or between the patient samples obtained before PCI and after the invasive procedure in both study groups.ConclusionsThese findings argue against the hypothesis that urine IL-18 may be clinically useful as a biomarker of CIN after radiological procedures requiring intravascular administration of iodinated contrast media. Further studies with larger sample sizes are needed to validate our findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Biochemistry - Volume 41, Issues 7–8, May 2008, Pages 544–547
نویسندگان
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