کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1971609 | 1538910 | 2008 | 4 صفحه PDF | دانلود رایگان |

ObjectivesContrast-induced nephropathy (CIN) is a complication that is underestimated in clinical practice after cardiac catheterization. Recently, the value of interleukin (IL)-18 as a novel biomarker for the detection of acute renal failure has been highlighted. In the present study, we sought to investigate whether urine IL-18 may be an early diagnostic marker of CIN.Design and methodsWe performed a nested case-control study using a hospital based cohort of all patients (n = 157) admitted for elective PCI for stable angina to the Uludag University School of Medicine between February 2007 and June 2007. We identified 15 patients (9.5%) with CIN. Controls were matched with cases at an attempted 2.5:1 ratio by age and gender. Urinary IL-18 values were measured before as well as 24 and 72 h after the PCI.ResultsNo statistically significant differences in urine IL-18 were detected between cases (n = 15) and controls (n = 36) or between the patient samples obtained before PCI and after the invasive procedure in both study groups.ConclusionsThese findings argue against the hypothesis that urine IL-18 may be clinically useful as a biomarker of CIN after radiological procedures requiring intravascular administration of iodinated contrast media. Further studies with larger sample sizes are needed to validate our findings.
Journal: Clinical Biochemistry - Volume 41, Issues 7–8, May 2008, Pages 544–547