کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1972000 1538996 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of PACAP on testosterone and 17β-estradiol production in the testis of wall lizard Podarcis sicula
ترجمه فارسی عنوان
نقش PACAP در تولید تستوسترون و 17β استرادیول در بیضه از مارمولک دیوار Podarcis sicula
کلمات کلیدی
PACAP؛ استروئیدوژنز؛ خزندگان؛ هورمون های استروئیدی جنسی؛ آنتاگونیست گيرنده PACAP
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide that in mammalian testis is involved in the control of testosterone and 17β-estradiol synthesis. A similar involvement was recently postulated in the testis of a nonmammalian vertebrate, the wall lizard Podarcis sicula. Indeed, we reported the presence of PACAP and its receptors throughout the reproductive cycle within both germ and somatic cells. Now, we investigated the effects of PACAP on steroidogenesis in significant periods of Podarcis reproductive cycle: winter stasis, reproductive period and summer stasis. Using different in vitro treatments, in the absence or presence of receptor antagonists, we demonstrated that in P. sicula testis PACAP is involved in the control of testosterone and 17β-estradiol production. In particular we demonstrated that treatment with PACAP induced a testosterone increase only in stasis periods (winter and summer stasis); differently they induced a 17β-estradiol production in all periods analyzed (summer stasis, winter stasis and reproductive period).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 191, January 2016, Pages 180–186
نویسندگان
, , , , , , ,