Essential oils of E. uniflora leaves protect liver injury induced by acetaminophen

The goal of this work was to evaluate the hepatoprotector activity of Eugenia uniflora leaves essential oil in mice by the determination of the biochemical parameters: thiobarbituric acid reactive species, δ-aminulevunilate dehydratase, glutathione-S-transferase and catalase activities, non-protein thiol, and plasmatic levels of aspartate aminotransferase and alanine aminotransferase. The E. uniflora leaves essential oil (200 mg/kg) restored all of the biochemical parameters modified by the injury caused by the acetaminophen (300 mg/kg), like non-protein thiol content, δ-aminulevunilate dehydratase and glutathione-S-transferase activities on mice's liver and also decreased the levels of thiobarbituric acid reactive species on kidneys. Moreover, the increase on plasma activities aspartate aminotransferase and alanine aminotransferase was also restored by the essential oil. The exposure to acetaminophen also increased lipid peroxidation in liver and kidney. This work shows for the first time the effect of E. uniflora leaves essential oil on attenuating the injury caused by acetaminophen on mice.