کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1974229 1060344 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does membrane fatty acid composition modulate mitochondrial functions and their thermal sensitivities?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Does membrane fatty acid composition modulate mitochondrial functions and their thermal sensitivities?
چکیده انگلیسی

We investigated the effect of modifying fatty acid modification of heart mitochondrial membranes by dietary intervention on the functions and thermal sensitivity of electron transport system complexes embedded in the inner mitochondrial membrane. Four groups of rats were fed diets differing in their fat (coconut, olive or fish oil) and antioxidant (fish oil with or without probucol) contents. After 16 weeks of feeding, the coconut and olive oil groups had lower long-chain n-3 polyunsaturated fatty acids contents and a lower unsaturation index compared to both fish oil groups. These differences in fatty acid composition were not related to any differences in the mitochondrial respiration rate induced at Complexes I, II or IV, or to differences in their thermal sensitivity. The coconut oil group showed a lower mitochondrial affinity for pyruvate at 5 °C (kmapp = 6.4 ± 1.8) compared to any other groups (kmapp = 3.8 ± 0.5; 4.7 ± 0.8; 3.6 ± 1.1, for olive, fish oil and fish oil and probucol groups, respectively). At least in rat heart, our results do not support a major impact of the fatty acid composition of the mitochondrial membrane on the function of mitochondrial enzymatic complexes or on their temperature sensitivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 149, Issue 1, January 2008, Pages 20–29
نویسندگان
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