Encapsulation of Aloe Vera extract into natural Tragacanth Gum as a novel green wound healing product

• Preparation of a wound healing agent based encapsulated Aloe Vera extract.
• Application of Tragacanth Gum as a non-cytotoxic wall material.
• Using a sonochemical/microemulsion process to produce nanocapsules.
• Cell viability of 98% against human fibroblast cells.
• Good wound healing activity with considerable migration rate of fibroblast cells.

Application of natural materials in wound healing is an interest topic due to effective treatment with no side effects. In this paper, Aloe Vera extract was encapsulated into Tragacanth Gum through a sonochemical microemulsion process to prepare a wound healing product. FESEM/EDX and FT-IR proved the successfully formation of the nanocapsules with spherical shape by cross-linking aluminum ions with Tragacanth Gum. The therapeutic characteristics of the prepared wound healing product were investigated using antimicrobial, cytotoxicity and wound healing assays. Relative high antimicrobial activities with the microbial reduction of 84, 91 and 80% against E. coli, S. aureus and C. albicans, a cell viability of 98% against human fibroblast cells and a good wound healing activity with considerable migration rate of fibroblast cells are the important advantages of the new formed wound healing product.

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