کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1986007 1540236 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sulfated polysaccharide heparin used as carrier to load hydrophobic lappaconitine
ترجمه فارسی عنوان
هپارین پلی ساکارید سولفات به عنوان حامل برای بارگذاری لاپاکونیتین هیدروفوب استفاده می شود
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• LA is simple to self-assemble into LMWH to form pH-sensitivity LMWH-LA.
• LMWH has a superior loading capacity of 24.3% (w/w).
• LMWH is a good template and has great potential to achieve synergistic effect of LA.
• LMWH-LA effectively resolves the late onset time and the short duration of LA.

One-step self-assembly was used to prepare pH-sensitive lappaconitine-loaded low-molecular-weight heparin (LMWH-LA) and to demonstrate that the sulfur group promotes dissolution and has synergistic effect on the analgesic property of lappaconitine (LA). The LMWH-LA was characterized in terms of releasing behavior, pH-sensitivity, analgesic activity and anticoagulation property. The drug loading level of LA in low-molecular-weight heparin (LMWH) reached 24.3% (w/w). The LA, self-assembled in LMWH, released faster in an acidic environment than that in neutral or alkaline environments. Analgesic experiments showed that the LMWH-LA had earlier onset time and longer duration than the LA. Compared with LMWH, the LMWH-LA can reduce clotting time more effectively. These results suggest that the LMWH is a good template and has great potential to achieve synergistic effect of LA. In addition, similar macromolecular structure can be used as a new natural polymeric carrier for loading hydrophobic alkaloids.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 84, March 2016, Pages 275–280
نویسندگان
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