A facile green approach to prepare core-shell hybrid PLGA nanoparticles for resveratrol delivery

• Solvent free green PLGA NPs were prepared using acrysol oil as solvent.
• Green NPs were smooth while standard NPs were porous due to solvent evaporation.
• An improvement in drug release, stability and biocompatibility was observed.
• NPs size was found to be a critical factor governing the cytotoxicity on MCF-7 cells.

Green approach has revolutionized the area of nanoparticles (NPs) synthesis by virtue of eco and health friendly protocols. Advancing this further, the study proposes a captivating solvent free method for the preparation of green PLGA-oil nanohybrids (G-PONHs) using acrysol oil and encapsulation of resveratrol therein. G-PONHs were structurally similar to the standard PONHs, but had larger particle size of 375 nm. Avoidance of organic solvents resulted in the formation of smooth NPs which showed a considerable improvement in drug release profile and antioxidant properties. G-PONHs exhibited superior biocompatibility with normal Vero cells, while the cytotoxicity on breast cancer cells was moderate in comparison to standard NPs owing to their large size. The size of NPs was found to be a critical factor governing the amplitude of cytotoxicity. The comparative high stability of G-PONHs further favors the tremendous potential of this novel preparation method and delivery platform.