In vitro aceclofenac release from IPN matrix tablets composed of chitosan-tamarind seed polysaccharide

• IPN microparticles using chitosan and tamarind seed polysaccharide polymer-blend was prepared using glutaraldehyde as cross-linker.
• The drug entrapment efficiency and average particle size of these microparticles was found to be 91.97 ± 1.30% and 498.12 ± 38.67 mm, respectively.
• These IPN microparticles were characterized by scanning electron microscopy (SEM) and powder X-ray diffraction (P-XRD) study.
• These matrix tablets showed sustained aceclofenac release over 8 h.

This communication describes the formulation and in vitro evaluation of IPN matrix tablets of aceclofenac. IPN microparticles using chitosan and tamarind seed polysaccharide blend was prepared using glutaraldehyde as cross-linker. The drug entrapment efficiency and average particle size of these microparticles was found to be 91.97 ± 1.30% and 498.12 ± 38.67 μm, respectively. These IPN microparticles were characterized by scanning electron microscopy (SEM) and powder X-ray diffraction (P-XRD) study. These microparticles were compressed with tablet excipients through direct compression technique. These matrix tablets showed sustained aceclofenac release over 8 h. These matrix tablets might be helpful to minimize dosing frequency and reduction of various side effects during prolong period of treatment.