کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1986593 1540256 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioactivity and biocompatibility of a chitosan-tobermorite composite membrane for guided tissue regeneration
ترجمه فارسی عنوان
فعالیت بیولوژیکی و سازگاری زیستی یک غشای کامپوزیت کیتوزان-تبرموریت برای بازسازی بافت هدایت شده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

A polymer-mineral composite membrane of the mucopolysaccharide derivative, chitosan, and calcium silicate hydrate phase, tobermorite, was prepared by solvent casting and characterised by scanning electron microscopy (SEM) and Fourier Transform infrared spectroscopy (FTIR). The bioactivity and biocompatibility of the chitosan-tobermorite composite were evaluated in vitro with respect to its potential for use as a biodegradable guided tissue regeneration (GTR) membrane. The in vitro bioactivity of the composite was confirmed by the formation of crystalline substituted hydroxyapatite on the surface of the embedded tobermorite particles in simulated body fluid. The presence of the composite membrane was found to enhance the growth of MG63 human osteosarcoma cells by up to 30%. The findings of this initial study have indicated that this novel chitosan-tobermorite composite may be a suitable material for GTR applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 64, March 2014, Pages 11–16
نویسندگان
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