کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1986693 1540251 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose
ترجمه فارسی عنوان
جذب دهانی امولسیون اسپری خشک شده با والسارتان بر اساس هیدروکسی پروپیلمیل سلولز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

The aim of this study was to develop a novel valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose (HPMC) with enhanced oral absorption. The valsartan-loaded redispersible dry emulsion was prepared by using a high-pressure homogenization and spray-drying process with water, Capryol 90, HPMC, and different surfactants, based on the results of the solubility study. The spray-dried emulsions formed small and homogeneous emulsions with a mean droplet emulsion size ranging from 133.5 to 152.5 nm at the dispersion state in water. The valsartan-loaded redispersible dry emulsion with HPMC/poloxamer 407 showed enhanced pH-independent valsartan release, resulting in a dramatically enhanced oral bioavailability of valsartan compared to the raw material and commercial product. Therefore, a formulation strategy using the redispersible dry emulsion with HPMC/poloxamer 407 is very effective for the development of a new dosage form containing valsartan.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 69, August 2014, Pages 222–228
نویسندگان
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