کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1986876 | 1540258 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carboxymethyl functionalization of amylopectin and its evaluation as a nanometric drug carrier
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Carboxymethyl functionalization of amylopectin and its evaluation as a nanometric drug carrier Carboxymethyl functionalization of amylopectin and its evaluation as a nanometric drug carrier](/preview/png/1986876.png)
چکیده انگلیسی
Carboxymethylation of amylopectin was accomplished by reacting it with monochloroacetic acid. The results of characterization study confirmed the carboxymethyl functionalization with degree of substitution of 1.25. Carboxymethyl amylopectin was found to be slightly more crystalline, appearing morphologically as polyhedral flakes with striated surface. Further, carboxymethylation of amylopectin modified its compression characteristic from fragmentary to plastic. Interaction of carboxymethyl amylopectin (0.001-0.005%, w/v) with chitosan (0.05-0.075% w/v) using ibuprofen (0.05%, w/v) as a model drug provided polyelectrolyte nanoparticles of size 182.7-353.3Â nm and 75-92% drug entrapment. The polyelectrolyte nanoparticles showed a sustained release of drug following zero-order kinetics with mechanism of release being combination of matrix erosion and diffusion through the matrix.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 62, November 2013, Pages 25-29
Journal: International Journal of Biological Macromolecules - Volume 62, November 2013, Pages 25-29
نویسندگان
Kanika Thakur, Munish Ahuja, Ashok Kumar,