کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987370 | 1540286 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction of a copper(II)–Schiff base complexes with calf thymus DNA and their antimicrobial activity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interaction of a copper(II)–Schiff base complexes with calf thymus DNA and their antimicrobial activity Interaction of a copper(II)–Schiff base complexes with calf thymus DNA and their antimicrobial activity](/preview/png/1987370.png)
چکیده انگلیسی
The interaction of a copper complexes containing Schiff bases with calf thymus (CT) DNA was investigated by spectroscopic methods. UV–vis, fluorescence and CD spectroscopies were conducted to assess their binding ability with CT DNA. The binding constants K have been estimated from 0.8 to 9.1 × 104 M−1. The percentage of hypochromism is found to be over 70% (from spectral titrations). The results showed that the copper(II) complexes could bind to DNA with an intercalative mode. Synergic action of Cu(II) complexes with ascorbic acid against Candida albicans induced the generation of free radicals and increased (more than 60 times) antimicrobial effect of these complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 48, Issue 2, 1 March 2011, Pages 319–325
Journal: International Journal of Biological Macromolecules - Volume 48, Issue 2, 1 March 2011, Pages 319–325
نویسندگان
D. Sabolová, M. Kožurková, T. Plichta, Z. Ondrušová, D. Hudecová, M. Šimkovič, H. Paulíková, A. Valent,