کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987604 | 1540320 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Consensus prediction of amyloidogenic determinants in amyloid fibril-forming proteins Consensus prediction of amyloidogenic determinants in amyloid fibril-forming proteins](/preview/png/1987604.png)
We combine the results of three prediction algorithms on a test set of 21 amyloidogenic proteins to predict amyloidogenic determinants. Two prediction algorithms are recently developed prediction algorithms of amyloidogenic stretches in protein sequences, whereas the third is a secondary structure prediction algorithm capable of identifying ‘conformational switches’ (regions that have both the propensity for α-helix and β-sheet). Surprisingly, the results of prediction agree well and also agree with experimentally investigated amyloidogenic regions. Furthermore, they suggest several previously not identified amino acid stretches as potential amyloidogenic determinants. Most predicted (and experimentally observed) amyloidogenic determinants reside on the protein surface of relevant solved crystal structures. It appears that a consensus prediction algorithm is more objective than individual prediction methods alone.
Journal: International Journal of Biological Macromolecules - Volume 41, Issue 3, 1 August 2007, Pages 295–300