کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987747 | 1540310 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice](/preview/png/1987747.png)
چکیده انگلیسی
Taspine solid lipid nanoparticles (Ta-SLN) and taspine solid lipid nanoparticles modified by galactoside (Ta-G2SLN) were prepared by the film evaporation-extrusion method. The nanoparticles were spherical or near-spherical particles with smooth surface, small size and high encapsulation efficiency. Ta-G2SLN and Ta-SLN showed significant inhibition on 7721 cell growth. Intravenous injection of either Ta-SLN or Ta-G2SLN resulted in a higher plasma and liver concentration and a longer retention time in mice compared with the administration of Ta. These results suggested that SLN tended to be preferentially delivered to the liver and Ta-G2SLN may further enhance liver targeting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 43, Issue 3, 1 October 2008, Pages 320-324
Journal: International Journal of Biological Macromolecules - Volume 43, Issue 3, 1 October 2008, Pages 320-324
نویسندگان
Wen Lu, Lang Chong He, Chang He Wang, Yan Hua Li, San Qi Zhang,