کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1987821 1540302 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Three-dimensional gastric cancer cell culture using nanofiber scaffold for chemosensitivity test
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Three-dimensional gastric cancer cell culture using nanofiber scaffold for chemosensitivity test
چکیده انگلیسی

A three-dimensional (3D) culture of cancer cells has long been advocated as a better model of the malignant phenotype that is most closely related to tumorigenicity in vivo. To investigate the sensitivity of cancer cells to anticancer drugs, nanofiber scaffolds composed of PHBV and collagen peptide were fabricated by electrospinning. A 3D culture of cancer cells was successfully achieved by the use of nanofiber scaffolds. From the result of a chemosensitivity test, it was found that higher concentrations of anticancer drugs were required to achieve a comparable cytotoxic effect in 3D culture due to their structural architecture. These data demonstrate that the electrospun nanofiber scaffolds can provide a 3D model particularly appropriate for investigating mechanisms involved in cancer cell sensitivity to anticancer drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 45, Issue 1, 1 July 2009, Pages 65–71
نویسندگان
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