کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987968 | 1540319 | 2007 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cell surface proteins in archaeal and bacterial genomes comprising “LVIVD”, “RIVW” and “LGxL” tandem sequence repeats are predicted to fold as β-propeller
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Proteins that share even low sequence homologies are known to adopt similar folds. The β-propeller structural motif is one such example. Identifying sequences that adopt a β-propeller fold is useful to annotate protein structure and function. Often, tandem sequence repeats provide the necessary signal for identifying β-propellers in proteins. In our recent analysis to identify cell surface proteins in archaeal and bacterial genomes, we identified some proteins that contain novel tandem repeats “LVIVD”, “RIVW” and “LGxL”. In this work, based on protein fold predictions and three-dimensional comparative modeling methods, we predicted that these repeat types fold as β-propeller. Further, the evolutionary trace analysis of all proteins constituting amino acid sequence repeats in β-propellers suggest that the novel repeats have diverged from a common ancestor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 41, Issue 4, 1 October 2007, Pages 454-468
Journal: International Journal of Biological Macromolecules - Volume 41, Issue 4, 1 October 2007, Pages 454-468
نویسندگان
Swathi Adindla, Krishna Kishore Inampudi, Lalitha Guruprasad,