Transcriptional inhibition of the Catalase gene in phosphine-induced oxidative stress in Drosophila melanogaster

- The phosphine (PH3)-induced toxicity mechanism was determined in Drosophila melanogaster.
- PH3 fumigation decreased aerobic respiration and increased H2O2 and lipid peroxide.
- PH3 downregulated catalase gene and protein levels.
- PH3 appears to induce oxidative stress by inhibiting CAT via the DRE/DREF system.