کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2010898 1066991 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases
ترجمه فارسی عنوان
مرور کلی از عوامل بیرونی و ذهنی در علت و پیشرفت بیماری های التهابی روده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

Inflammatory bowel diseases (IBD) are chronic, relapsing disorders affecting gastrointestinal (GI) tract and associated with intestinal mucosa damage and inflammation. The principal therapeutic goals in IBD include control of the intestinal inflammation and treatment of the major symptoms, mainly abdominal pain and diarrhea. Current therapeutic strategies for IBD rely on the use of non-specific anti-inflammatory agents and immunosuppressive drugs (e.g. aminosalicylates, monoclonal antibodies, and antibiotics), which cause severe side effects, and – in a significant number of patients – do not induce long-term benefits.In this review, we summarize the epidemiology and the most important risk factors of IBD, including genetic, immunological and environmental. Our main focus is to discuss pharmacological targets for current and future treatments of IBD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 66, Issue 5, October 2014, Pages 766–775
نویسندگان
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