کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2011902 1067018 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats
ترجمه فارسی عنوان
اثر تزریق میکروارگانیسم هیستامین در قشر کورتونی قدامی در رفتارهای مرتبط با درد ناشی از فرمالین در موش های صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

BackgroundThe present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats.MethodsTwo stainless steel guide canulas were bilaterally implanted into the ACC of anaesthetized rats. For induction of pain, intraplantar (ipl) injection of a 2.5% formalin solution was performed. The duration of paw licking/biting and the number of paw flinching were recorded in 5 min blocks for 60 min. Locomotor activity was assessed using an open-field test.ResultsFormalin produced a marked biphasic pattern of pain. Histamine reduced the second phases of paw licking/biting and flinching. Mepyramine (2 μg/side) prevented the suppressive effect of histamine (1 μg/side) on second phase of pain, but at a dose of 8 μg/side it did not inhibit the suppressive effects of 4 μg/side of histamine. Ranitidine at doses of 2 and 8 μg/side prevented histamine (1 and 4 μg/side)-induced antinociception. Thioperamide not only suppressed the second phases of pain, but also increased the suppressive effect of histamine. Naloxone prevented suppressive effects of histamine and thioperamide on pain. Mepyramine (8 μg/side) suppressed locomotor activity.ConclusionThe results of the present study showed pain suppressing effects for histamine. Histamine H2 and H3, and to a lesser extent, H1 receptors might be involved in histamine-induced antinociception. Opioid receptors might be involved in suppressive effects of histamine and thioperamide.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 67, Issue 3, June 2015, Pages 593–599
نویسندگان
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