کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2012001 1067021 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of desipramine on gene expression in the mouse frontal cortex – Microarray study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Effect of desipramine on gene expression in the mouse frontal cortex – Microarray study
چکیده انگلیسی

BackgroundThese studies aimed to identify the genes differentially expressed in the frontal cortex of mice treated repeatedly with either saline or desipramine (DMI).MethodsDifferences in gene expression in the mouse frontal cortex were studied using a whole-genome microarray approach.ResultsThe analyses revealed a group of 88 transcripts (18 genes) that were differentially expressed between the mice treated with saline and those treated with DMI. These genes include Spnb2, Mef2c, Ncam1, Hsp90ab1, Kif1b, Ddx6 and Gsk3b, which were connected in the gene relationship network.ConclusionsIt appears that one week of DMI administration measurably altered the expression of a small number of genes, including genes connected with neuroplasticity and cytoskeletal changes, the regulation of calcium levels in the cell or translation processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 67, Issue 2, April 2015, Pages 345–348
نویسندگان
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