کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2012075 | 1067023 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short communication - Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg2+ seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined the effectiveness of desialylation in reducing persistent seizure-like activity. We show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low Mg2+. These findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 63, Issue 3, May–June 2011, Pages 840–844
Journal: Pharmacological Reports - Volume 63, Issue 3, May–June 2011, Pages 840–844
نویسندگان
Elena Isaeva, Irina Lushnikova, Alina Savrasova, Galina Skibo, Gregory L. Holmes, Dmytro Isaev,